PAF-R rabbit pAb
Rif. EK-ES6880
| 50µl | 188,00 € | ||
| 100µl | 316,00 € |
Informazioni sul prodotto
- PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Proprietà chimiche
Richiesta tecnica su: EK-ES6880 PAF-R rabbit pAb
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