ABT 888

CAS: 912444-00-9

Rif. TR-A112580

Informazioni sul prodotto

• Nome: ABT 888
• Sinonimi: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, 1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-, 1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide, 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide, A 861695, A861695, Abt 888, Abt888, Unii-01O4K0631N, Veliparib, Veliparib ER

Descrizione

Applications ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
References Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 244.29
• Formula: C₁₃H₁₆N₄O
• Colore/Forma: Neat
• InChI: InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
• InChI key: InChIKey=JNAHVYVRKWKWKQ-CYBMUJFWSA-N
• SMILES: C[C@]1(c2nc3cccc(C(N)=O)c3[nH]2)CCCN1