4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine

CAS: 956025-99-3

Rif. TR-A602985

Informazioni sul prodotto

• Nome: 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
• Sinonimi: 3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 3-BrB-PP1
• Marchio: TRC

Descrizione

Applications 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival.
References Eblen, S., et al.: J. Biol. Chem., 278, 14926 (2003), Lindsley, C., et al.: Bioorg. Med. Chem. Lett., 15, 761 (2005), Manning, B., et al.: Cell, 129, 1261 (2007), Heerding, D., et al.: J. Med. Chem., 51, 5663 (2008),

Proprietà chimiche

• Peso molecolare: 360.25
• Formula: C₁₆H₁₈BrN₅
• Colore/Forma: Neat
• InChI: InChI=1S/C16H18BrN5/c1-16(2,3)22-15-13(14(18)19-9-20-15)12(21-22)8-10-5-4-6-11(17)7-10/h4-7,9H,8H2,1-3H3,(H2,18,19,20)
• InChI key: InChIKey=FTICVONBLRGQJW-UHFFFAOYSA-N
• SMILES: CC(C)(C)n1nc(Cc2cccc(Br)c2)c2c(N)ncnc21