Aramchol

CAS: 246529-22-6

Rif. TR-A765150

Informazioni sul prodotto

• Nome: Aramchol
• Sinonimi: (3ß,5ß,7a,12a)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]-cholan-24-oic Acid, (3ß)-Arachidylamido-7a,12a-dihydroxy-5ß-cholan-24-oic Acid, C20-FABAC, (3β)-Arachidylamido-7α,12α-dihydroxy-5β-cholan-24-oic acid, (3β,5β,7α,12α)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid, (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid, C₂₀-FABAC, Cholan-24-oic acid, 7,12-dihydroxy-3-[(1-oxoeicosyl)amino]-, (3β,5β,7α,12α)-

Descrizione

Applications Aramchol is a fatty acid conjugate that exhibits hypocholesterolemic effects. Studies have shown that aramchol suppresses the activity of stearoyl-CoA desaturase (SCD), which leads to reduction of obesity, fatty liver and insulin resistance.
References Leikin-Frenkel, A., et al.: Arch Med Res. 41, 397 (2010); Gonen, A., et al.: Pathobiology 70, 215 (2003)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 702.1
• Formula: C₄₄H₇₉NO₅
• Colore/Forma: Neat
• InChI: InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1
• InChI key: InChIKey=SHKXZIQNFMOPBS-OOMQYRRCSA-N
• SMILES: CCCCCCCCCCCCCCCCCCCC(=O)N[C@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](O)[C@@H]1[C@@H]2C[C@H](O)[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)O