Artemether Tetrahydrofuran Acetate

CAS: 181528-64-3

Rif. TR-A777415

Informazioni sul prodotto

• Nome: Artemether Tetrahydrofuran Acetate
• Sinonimi: (3aS,4R,6aS,7R,8S,10R,10aR)-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol 10-Acetate, [3aS-(3aa,4a,6aa,7ß,8ß,10a,10aS*)]-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol Acetate, Artemether Ph. Int. Impurity C, Artemether tetrahydrofuran acetate, β-Artemetherfurano acetate, 2H,10H-Furo[3,2-i]-2-benzopyran-10-ol, octahydro-8-methoxy-4,7-dimethyl-, 10-acetate, (3aS,4R,6aS,7R,8S,10R,10aR)-, 2H,10H-Furo[3,2-i][2]benzopyran-10-ol, octahydro-8-methoxy-4,7-dimethyl-, acetate, [3aS-(3aα,4α,6aα,7β,8β,10α,10aS*)]-, 2H,10H-Furo[3,2-i][2]benzopyran-10-ol, octahydro-8-methoxy-4,7-dimethyl-, acetate, (3aS,4R,6aS,7R,8S,10R,10aR)-

Descrizione

Applications A metabolite of Artemether (A777400) and derivative of the antimalarial drug Artemisinin (A777500). Studies suggest that it may display neurotoxicity in animals due to its interaction with iron.
References Smith, S.L. et al.: Neurotoxicology, 19, 557 (1998); Blum, W. et al.: J. Chrom. B Biomed. Sci. Appl., 710, 101 (1998);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 298.37
• Formula: C₁₆H₂₆O₅
• Colore/Forma: Neat
• InChI: InChI=1S/C16H26O5/c1-9-5-6-13-10(2)14(18-4)21-15(20-11(3)17)16(13)12(9)7-8-19-16/h9-10,12-15H,5-8H2,1-4H3/t9-,10-,12+,13+,14+,15+,16-/m1/s1
• InChI key: InChIKey=PJRDDUABDHLSPP-QYHITDJBSA-N
• SMILES: CO[C@H]1O[C@H](OC(C)=O)[C@@]23OCC[C@H]2[C@H](C)CC[C@H]3[C@H]1C