1,3-Bis(2-chloroethyl)urea

CAS: 2214-72-4

Rif. TR-B419015

Informazioni sul prodotto

• Nome: 1,3-Bis(2-chloroethyl)urea
• Sinonimi: Urea, N,N'-bis(2-chloroethyl)-, Urea, 1,3-bis(2-chloroethyl)- (6CI,7CI,8CI), NSC 36198, Urea, N,N'-bis(2-chloroethyl)-, Ai3-08682, Nsc 36198, Urea, 1,3-bis(2-chloroethyl)-
• CAS: 2214-72-4

Descrizione

Stability Hygroscopic, Unstable in Solution
Applications 1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine (C183875), an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 185.05
• Formula: C₅H₁₀Cl₂N₂O
• Colore/Forma: Neat
• InChI: InChI=1S/C5H10Cl2N2O/c6-1-3-8-5(10)9-4-2-7/h1-4H2,(H2,8,9,10)
• InChI key: InChIKey=VBWBRZHAGLZNST-UHFFFAOYSA-N
• SMILES: O=C(NCCCl)NCCCl