(S)-(-)-Blebbistatin

CAS: 856925-71-8

Rif. TR-B592500

Informazioni sul prodotto

• Nome: (S)-(-)-Blebbistatin
• Sinonimi: 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-, (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one, (-)-Blebbistatin

Descrizione

Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. Blebbistatin blocks both blebbing and cytokinesis at 50-100µM.[Blebbistatin:a]D= -103 (c= 1.21 CHCl3)(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneBlebbistatin is a selective inhibitor of nonmuscle myosin II; Blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 292.33
• Formula: C₁₈H₁₆N₂O₂
• Colore/Forma: Light Yellow To Yellow
• InChI: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
• InChI key: InChIKey=LZAXPYOBKSJSEX-GOSISDBHSA-N
• SMILES: Cc1ccc2c(c1)C(=O)[C@]1(O)CCN(c3ccccc3)C1=N2