(S)-1-Boc-3-hydroxypiperidine

CAS: 143900-44-1

Rif. TR-B656650

Informazioni sul prodotto

• Nome: (S)-1-Boc-3-hydroxypiperidine
• Sinonimi: (3S)-3-Hydroxy-1-piperidinecarboxylic Acid 1,1-dimethylethyl Ester, (S)-3-Hydroxypiperidine-1-carboxylic Acid tert-Butyl Ester, (S)-N-Boc-3-hydroxypiperidine, (S)-tert-Butyl 3-Hydroxypiperidine-1-carboxylate, 1,1-Dimethylethyl (3S)-3-Hydroxy-1-piperidinecarboxylate, 1-Boc-(3S)-3-hydroxypiperidine, tert-Butyl (S)-3-Hydroxypiperidine-1-carboxylate, (S)-N-Boc-3-hydroxypiperidine, (S)-1-N-Boc-3-Hydroxy-Piperidine, (S)-3-Hydroxy-Piperidine-1-Carboxylic Acid Tert-Butyl Ester, (S)-3-Hydroxy-1-(Tert-Butoxycarbonyl)Piperidine, (S)-1-Boc-3-Piperidinol, (S)-N-(Tert-Butoxycarbonyl)-3-Hydroxypiperidine Hydrochloride, (S)-N-Boc-3-Hydroxy Piperidine, (S)-Tert Butyl-3-Hydroxypiperidine-1-Carboxylate, tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate, (S)-N-BOC-3-piperidinol, (S)-N-Boc-3-piperidine

Descrizione

Applications (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, L., et al.: Tetrahedron Lett., 58, 1644 (2017); Ju, X., et al.: Org. Process Res. Dev., 18, 827 (2014)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 201.26
• Formula: C₁₀H₁₉NO₃
• Colore/Forma: Neat
• InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
• InChI key: InChIKey=UIJXHKXIOCDSEB-QMMMGPOBSA-N
• SMILES: CC(C)(C)OC(=O)N1CCC[C@H](O)C1