N-Cbz-5-hydroxy-6-oxo-N-(2,4,6-trifluorobenzyl)-1,6-dihydropyrimidine-4-carboxamide

Rif. TR-C227660

Informazioni sul prodotto

• Nome: N-Cbz-5-hydroxy-6-oxo-N-(2,4,6-trifluorobenzyl)-1,6-dihydropyrimidine-4-carboxamide

Descrizione

Applications N-Cbz-5-hydroxy-6-oxo-N-(2,4,6-trifluorobenzyl)-1,6-dihydropyrimidine-4-carboxamide is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 462.379
• Formula: C₂₁H₁₇F₃N₄O₅
• Colore/Forma: Grey Solid
• InChI: InChI=1S/C21H17F3N4O5/c22-12-6-14(23)13(15(24)7-12)8-25-19(30)17-18(29)20(31)28-16(27-17)9-26-21(32)33-10-11-4-2-1-3-5-11/h1-7,29H,8-10H2,(H,25,30)(H,26,32)(H,27,28,31)
• InChI key: InChIKey=HENYZYQASSRBQZ-UHFFFAOYSA-N
• SMILES: O=C(NCc1nc(C(=O)NCc2c(F)cc(F)cc2F)c(O)c(=O)[nH]1)OCc1ccccc1