2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin

CAS: 5638-58-4

Rif. TR-C366253

Informazioni sul prodotto

• Nome: 2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin
• Sinonimi: 2-chloro-1,3,2?5-oxazaphosphinane 2-oxide

Descrizione

Applications 2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin is an intermediate in the synthesis of N-Dides(2-chloroethyl) N-(2-Hydroxyethyl),N-(2-ethoxyethyl) Cyclophosphamide (C984610) which is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 155.52
• Formula: C₃H₇ClNO₂P
• Colore/Forma: Neat
• InChI: InChI=1S/C3H7ClNO2P/c4-8(6)5-2-1-3-7-8/h1-3H2,(H,5,6)
• InChI key: InChIKey=KTJQXXIVWRXBCC-UHFFFAOYSA-N
• SMILES: O=P1(Cl)NCCCO1