1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole

CAS: 13551-86-5

Rif. TR-C592035

Informazioni sul prodotto

• Nome: 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole
• Sinonimi: 1-chloro-3-(2-nitroimidazol-1-yl)propan-2-ol, 1H-Imidazole-1-ethanol, α-(chloromethyl)-2-nitro-, α-(Chloromethyl)-2-nitro-1H-imidazole-1-ethanol, Ro 07-0269, Imidazole-1-ethanol, α-(chloromethyl)-2-nitro-

Descrizione

Applications 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 205.599
• Formula: C₆H₈ClN₃O₃
• Colore/Forma: Neat
• InChI: InChI=1S/C6H8ClN3O3/c7-3-5(11)4-9-2-1-8-6(9)10(12)13/h1-2,5,11H,3-4H2
• SMILES: O=[N+]([O-])c1nccn1CC(O)CCl