N-Deacetyl Colchiceine

CAS: 3482-37-9

Rif. TR-D198900

Informazioni sul prodotto

• Nome: N-Deacetyl Colchiceine
• Sinonimi: (7S)-7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one, (7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one, (7S)-7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one, (S)-7-Amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one, (S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo(a)heptalen-9(5H)-one, 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one, Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)- (9CI), Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (7S)-, Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)-, Brn 3008992, Colchiceine, N-deacetyl-, Colchiceine, N-deacetyl- (8CI), Colchiceine, N-deacetyl- (VAN) (8CI), Colchicinic acid, O,O′,O′′-trimethyl-, Colchicinic acid, trimethyl-, Deacetylcholchiceine, Deacetylcolchiceine, Desacetylcholchiceine, Desacetylcolchiceine, N-Deacetylcolchiceine, Nsc 36796, Skf 284

Descrizione

Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Tanaka, H., et al.: Canc. Res., 69, 6978 (2009), D'Elia, M., et al.: Chem. Biol., 16, 548 (2009),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 343.37
• Formula: C₁₉H₂₁NO₅
• Colore/Forma: Neat
• InChI: InChI=1S/C19H21NO5/c1-23-16-8-10-4-6-13(20)12-9-15(22)14(21)7-5-11(12)17(10)19(25-3)18(16)24-2/h5,7-9,13H,4,6,20H2,1-3H3,(H,21,22)/t13-/m0/s1
• InChI key: InChIKey=IRVWPZRYDQROLU-ZDUSSCGKSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1[C@@H](N)CC2