N-Deacetyl Colchiceine

CAS: 3482-37-9

Rif. TR-D198900

Informazioni sul prodotto

• Nome: N-Deacetyl Colchiceine
• Sinonimi: Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (7S)-, Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)-, Colchiceine, N-deacetyl- (8CI), Colchicinic acid, O,O',O''-trimethyl- (6CI,7CI), (7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one, Deacetylcolchiceine, Desacetylcolchiceine, N-Deacetylcolchiceine, NSC 36796
• Marchio: TRC
• Descrizione: Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Tanaka, H., et al.: Canc. Res., 69, 6978 (2009), D'Elia, M., et al.: Chem. Biol., 16, 548 (2009),

Proprietà chimiche

• Peso molecolare: 343.37
• Formula: C₁₉H₂₁NO₅
• Colore/Forma: Neat
• InChI: InChI=1S/C19H21NO5/c1-23-16-8-10-4-6-13(20)12-9-15(22)14(21)7-5-11(12)17(10)19(25-3)18(16)24-2/h5,7-9,13H,4,6,20H2,1-3H3,(H,21,22)/t13-/m0/s1
• InChI key: InChIKey=IRVWPZRYDQROLU-ZDUSSCGKSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1[C@@H](N)CC2