N-Desmethyl Imatinib Dimesylate

Rif. TR-D292348

Informazioni sul prodotto

• Nome: N-Desmethyl Imatinib Dimesylate
• Sinonimi: N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide Dimesylate

Descrizione

Stability Hygroscopic
Applications N-Desmethyl Imatinib Dimesylate is a by-product of the synthesis of N-Desmethyl Imatinib Mesylate (D292345), a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
References Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 479.58210816
• Formula: C₂₈H₂₉N₇O•C₃H₈O₂S
• Colore/Forma: Neat
• InChI: InChI=1S/C9H10N2O4.ClH/c10-5-1-2-6(7(12)3-5)9(15)11-4-8(13)14;/h1-3,12H,4,10H2,(H,11,15)(H,13,14);1H
• InChI key: InChIKey=LKNHGIWKJBRBJQ-UHFFFAOYSA-N
• SMILES: Cl.Nc1ccc(C(=O)NCC(=O)O)c(O)c1