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4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine
CAS: 630125-91-6
Rif. TR-E924295
250mg | 2.172,00 € |
Informazioni sul prodotto
- 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
Applications 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References El-Gamal, M. I., et al.: Bull. Korean Chem. Soc., 33, 1571-1576 (2012); Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);
Proprietà chimiche
Richiesta tecnica su: TR-E924295 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine
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