Hydroxy Cyclophosphamide Semicarbazone-d4 (>80%)

CAS: 53948-46-2

Rif. TR-H926307

Informazioni sul prodotto

• Nome: Hydroxy Cyclophosphamide Semicarbazone-d4 (>80%)
• Sinonimi: N,N-bis(2-chloroethyl)phosphorodiamidic Acid 3-[2-(Aminocarbonyl)hydrazinylidene]propyl Ester-d4, NSC 319519-d4, Aldophosphamide Semicarbazone-d4

Descrizione

Stability Hygroscopic
Applications Isotope labelled Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 338.16
• Formula: C₈H₁₄D₄Cl₂N₅O₃P
• Purezza: >80%
• Colore/Forma: Neat
• InChI: InChI=1S/C8H18Cl2N5O3P/c9-2-5-15(6-3-10)19(12,17)18-7-1-4-13-14-8(11)16/h4H,1-3,5-7H2,(H2,12,17)(H3,11,14,16)/b13-4+/i2D2,3D2
• InChI key: InChIKey=DDSWASMKEIRTLV-DIWMPQAJSA-N
• SMILES: [2H]C([2H])(Cl)CN(CC([2H])([2H])Cl)P(N)(=O)OCC/C=N/NC(N)=O