5-Methoxyindole-3-acetonitrile-d2

CAS: 2436-17-1

Rif. TR-M262819

Informazioni sul prodotto

• Nome: 5-Methoxyindole-3-acetonitrile-d2
• Sinonimi: 5-Methoxy-1H-indole-3-acetonitrile-d2, (5-Methoxy-1H-indol-3-yl)acetonitrile-d2, 3-(Cyanomethyl)-5-methoxyindole-d2, 5-Methoxyindole-3-acetonitrile, (5-methoxy-1H-indol-3-yl)acetonitrile

Descrizione

Applications 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen re
References Barchas, et al.: Nature, 214, 919 (1967); Glass, J.D., et al.: Science, 214, 821 (1981)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 188.222
• Formula: C₁₁D₂H₈N₂O
• Colore/Forma: Neat
• InChI: InChI=1S/C11H10N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4H2,1H3/i4D2
• SMILES: [2H]C([2H])(C#N)c1c[nH]c2ccc(OC)cc12