ML-213

CAS: 489402-47-3

Rif. TR-M425300

Informazioni sul prodotto

• Nome: ML-213
• Sinonimi: (1R,3R,4S)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide

Descrizione

Applications ML-213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). ML-213 displays >80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.
References Rundfeldt, C., et al.: Eur. J. Pharmacol., 336, 243 (1997); Singh, N., et al.: Brain, 126, 2726 (2003); Munro, G., et al.: J. Med. Chem., 50, 2576 (2007); Qi, J., et al.: Eur. J. Med. Chem., 46, 934 (2011);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 257.371
• Formula: C₁₇H₂₃NO
• Colore/Forma: Neat
• InChI: InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19)/t13-,14+,15-/m1/s1
• InChI key: InChIKey=SIQGKPGBLYKQBB-UHFFFAOYSA-N
• SMILES: Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1