Osthole

CAS: 484-12-8

Rif. TR-O703570

Informazioni sul prodotto

• Nome: Osthole
• Sinonimi: 7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one, 7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, 8-(3-Methyl-2-butenyl)herniarin, NSC 31868, Osthol, Ostol, Ostole, NSC 31868, Osthol, Ostol, Ostole, 7-Methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one, 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin, 7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, 8-(3-Methyl-2-butenyl)herniarin, 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one, 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-, 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-, Common Cnidium Fruit Extract, Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-

Descrizione

Applications Osthole inhibits the PI3K/Akt pathway thus inhibiting insulin-like growth factor-1 (IGF-1)-induced epithelial-to-mesenchymal transition (EMT) in brain cancer. Osthole may be used in the treatment of Glioblastoma multiforme (GBM).
References Lin, Y., et. al.: J. Agr. Food Chem., 62, 5061 (2014)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 244.29
• Formula: C₁₅H₁₆O₃
• Colore/Forma: White To Off-White
• InChI: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
• InChI key: InChIKey=LIVCJMNSRBXFAY-UHFFFAOYSA-N
• SMILES: CC(c1ccc(N2CCN(C)CC2)c(Cl)c1Cl)c1ccc(N2CCN(C)CC2)c(Cl)c1Cl