Palbociclib Tri-O-isobutyryl-β-D-glucuronic Acid Methyl Ester

Rif. TR-P139930

Informazioni sul prodotto

• Nome: Palbociclib Tri-O-isobutyryl-β-D-glucuronic Acid Methyl Ester
• Sinonimi: (2R,3R,4S,5S,6S)-2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate)
• Marchio: TRC
• Descrizione: Applications Palbociclib Tri-O-isobutyryl-β-D-glucuronic Acid Methyl Ester is an intermediate in synthesizing Palbociclib N-β-D-Glucuronide Sodium Salt (P139910), a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

Proprietà chimiche

• Peso molecolare: 847.95
• Formula: C₄₃H₅₇N₇O₁₁
• Colore/Forma: Neat
• InChI: InChI=1S/C22H12/c1-3-13-7-9-18-12-16-6-2-4-14-8-10-17-11-15(5-1)19(13)21(18)22(17)20(14)16/h1-12H
• InChI key: InChIKey=YFIJJNAKSZUOLT-UHFFFAOYSA-N
• SMILES: c1cc2ccc3cc4cccc5ccc6cc(c1)c2c3c6c54