Palbociclib-d4 Hydrochloride

CAS: 571190-30-2

Rif. TR-P139937

Informazioni sul prodotto

• Nome: Palbociclib-d4 Hydrochloride
• Sinonimi: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one-d4 Hydrochloride, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one-d4 Hydrochloride, Ibrance-d4 Hydrochloride, PD 0332991-d4 Hydrochloride, PD 332991-d4 Hydrochloride, PD 991-d4 Hydrochloride, 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one, 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one, Ibrance, Otava-Bb 1115529, Palbociclib, Palbociclib base, Palbocyclib, Pd 332991, Pd 991, Pd-0332991, Pd0332991, Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-

Descrizione

Applications Palbociclib-d4 Hydrochloride is an intermediate in synthesizing Palbociclib-d4 (P139901), an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 465.58 + (36.46)
• Formula: C₂₅H₂₇D₄N₇O₂·HCl
• Colore/Forma: Neat
• InChI: InChI=1S/C25H31N7O2.ClH/c1-16-20-15-28-25(29-21-9-8-19(14-27-21)31-12-10-26-11-13-31)30-23(20)32(18-6-4-5-7-18)24(33)22(16)17(2)34-3;/h8-9,14-15,18,26H,2,4-7,10-13H2,1,3H3,(H,27,28,29,30);1H/i10D2,11D2
• SMILES: CS(=O)(=O)NC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]