Piperaquine Tetraphosphate

CAS: 911061-10-4

Rif. TR-P480050

Informazioni sul prodotto

• Nome: Piperaquine Tetraphosphate
• Sinonimi: 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis[7-chloroquinoline] Tetraphosphate

Descrizione

Applications Piperaquine is a 4-aminoquinoline derivative used as an antimalarial agent. Piperaquine interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites. It is commonly used in combination with Dihydroartemisinin (D448360) for the treatment of multi-drug resistant falciparum malaria.
References Nguyen, T.M.T. et al.: Tap Chi Duoc Hoc, 57, 22 (2007); Song, J. et al.: Malaria J., 10, 231 (2011);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 927.49
• Formula: C₂₉H₃₂Cl₂N₆•4H₃PO₄
• Colore/Forma: Neat
• InChI: InChI=1S/C29H32Cl2N6/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29/h2-9,20-21H,1,10-19H2
• InChI key: InChIKey=UCRHFBCYFMIWHC-UHFFFAOYSA-N
• SMILES: Clc1ccc2c(N3CCN(CCCN4CCN(c5ccnc6cc(Cl)ccc56)CC4)CC3)ccnc2c1