Sacubitril Calcium

CAS: 1369773-39-6

Rif. TR-S080900

Informazioni sul prodotto

• Nome: Sacubitril Calcium
• Sinonimi: [S-(R*,S*)]-?-[(3-Carboxy-1-oxopropyl)amino]-a-methyl-,[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Calcium salt, (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester Calcium salt, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester Calcium salt, AHU 377 Calcium salt, (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt, (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt, AHU-377 hemicalcium salt, AHU377 Calcium salt, Sacubitril Hemicalcium, Sacubitril Hemicalcium salt, [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-, Sacubitril Calcium, SacubitrilValsartan Sodium, (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl) amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)

Descrizione

Applications Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 430.52
• Formula: C₂₄H₂₈NOCa₂
• Colore/Forma: Neat
• InChI: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/p-1/t17-,21?/m1/s1
• InChI key: InChIKey=PYNXFZCZUAOOQC-OQHSHRKDSA-M
• SMILES: CCOC(=O)[C@H](C)CC(Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)[O-]