Tenofovir Disoproxil Fumarate

CAS: 202138-50-9

Rif. TR-T018505

Informazioni sul prodotto

• Nome: Tenofovir Disoproxil Fumarate
• Sinonimi: 5-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid 1,9-bis(1-methylethyl) ester 5-oxide (2E)-2-butenedioate (1:1), 5-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid bis(1-methylethyl) ester 5-oxide (2E)-2-butenedioate (1:1), (R)-5-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic acid bis(1-methylethyl) ester 5-oxide (E)-2-butenedioate (1:1), GS 4331-05, PMPA Prodrug, Tenfovir disoproxil fumarate, Tenofovir DF, Virea, Viread, BPPF
• Marchio: TRC
• Descrizione: Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Proprietà chimiche

• Peso molecolare: 635.51
• Formula: C₁₉H₃₀N₅O₁₀P·C₄H₄O₄
• Colore/Forma: White To Off-White
• InChI: InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
• InChI key: InChIKey=WPIDCVJSAMWXHR-KPJQVXLKSA-N
• SMILES: CC(C)C1(C)CCOP(=O)(CO[C@H](C)Cn2cnc3c(N)ncnc32)OC1.O=C(O)/C=C/C(=O)O.O=C(O)O.O=C(O)O