CymitQuimica ha oltre 25 partner, tra i quali spicca il fornitore TargetMol
We have reached an agreement with TargetMol: CymitQuimica clients will benefit for a 20% discount on all TargetMol products until the end of the year.On our website you can find the products offered by this partner, which has become one of the world's most recognised compound libraries and small molecule inhibitors supplier. TargetMol offers approximately 120 compound libraries and a wide range of chemical products and kits for life sciences.
Finisce il 31 dic( 8 giorni restanti )
Pimavanserin
CAS:<p>Pimavanserin is a potent 5-HT2A inverse agonist, used to treat Parkinson's psychosis.</p>Formula:C25H34FN3O2Purezza:97.84% - 99.69%Colore e forma:Pale Yellow To Pale Orange SolidPeso molecolare:427.55Benzidine orange
CAS:Benzidine orange (DCC-1802) shows mutagenic and carcinogenic activity.Formula:C32H24Cl2N8O2Purezza:≥98%Colore e forma:Orange Solid PowderPeso molecolare:623.49EGFR-IN-160
CAS:EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).Formula:C15H12N2O4Colore e forma:SolidPeso molecolare:284.27SHP2-IN-37
SHP2-IN-37 (compound C5) is a potent allosteric inhibitor selective for SHP2, with an IC50 of 0.023 μM. It exhibits antiproliferative effects on KYSE-520 and MV-411 cells, with IC50 values of 6.97 μM and 0.67 μM, respectively.Formula:C19H22Cl2N4O2SColore e forma:SolidPeso molecolare:440.08405PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Formula:C39H42Cl2N8O9Colore e forma:SolidPeso molecolare:836.24518RU 59063
CAS:RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands.Formula:C17H18F3N3O2SPurezza:99.09%Colore e forma:SolidPeso molecolare:385.4PPA-037
CAS:<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Formula:C25H27N7Colore e forma:SolidPeso molecolare:425.53GGACK hydrochloride
<p>GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Formula:C14H26Cl2N6O5Colore e forma:SolidPeso molecolare:428.13417E3 ligase Ligand 66
CAS:<p>E3ligaseLigand 66 is an E3 ligase ligand that facilitates the recruitment of IAP proteins. It can be linked with SARS-CoV-2 Mpro ligand 1 via a linker to form PROTACBP-198.</p>Formula:C26H34N4O4SColore e forma:SolidPeso molecolare:498.64Apoptosis inducer 37
Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.Formula:C27H37BrN2O4SColore e forma:SolidPeso molecolare:564.16574(1S,2R,7S)-Sitafloxacin
CAS:<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Formula:C19H18ClF2N3O3Colore e forma:SolidPeso molecolare:409.81Antibacterial agent 275
<p>Antibacterialagent 275 (Ⅲ1) is an antibacterial compound with a λmax value of 730 nm. It is applicable for research in antimicrobial photodynamic therapy (aPDT).</p>Formula:C108H118Br4N8O4Colore e forma:SolidPeso molecolare:1906.60095Sivelestat sodium tetrahydrate
CAS:Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM.Formula:C20H29N2NaO11SPurezza:99.68%Colore e forma:SolidPeso molecolare:528.51TrxR-IN-8
CAS:TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.Formula:C16H16INO2Colore e forma:SolidPeso molecolare:381.21BAY 74-4113
CAS:BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.Formula:C26H20F2N2O3SColore e forma:SolidPeso molecolare:478.51IRE1-IN-2
<p>IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.</p>Formula:C16H20O6Colore e forma:SolidPeso molecolare:308.12599CDK9 degrader-1
CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 µM). It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 µM). CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.Formula:C32H34Cl2N6O4Colore e forma:SolidPeso molecolare:637.56Betamethasone disodium phosphate
CAS:<p>Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) has anti-inflammatory activity and may be used in the study of rheumatoid arthritis.</p>Formula:C22H28FNa2O8PPurezza:99.37%Colore e forma:White PowderPeso molecolare:516.41TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formula:C23H21FN4O2Colore e forma:SolidPeso molecolare:404.16485Dienestrol diacetate
CAS:Dienestrol diacetate, a derivative of the synthetic non-steroid phenolic compound, DIENESTROL, exhibits estrogenic activities.Formula:C22H22O4Purezza:98%Colore e forma:SolidPeso molecolare:350.41
