CymitQuimica ha oltre 25 partner, tra i quali spicca il fornitore TargetMol

ATPase-IN-6 is an inhibitor of H+/K+-ATPase (ATPase) and a derivative of imidazopyridine. It exhibits significant antiviral activity against various viruses, such as HIV-1 and SARS-CoV-2. ATPase-IN-6 is applicable in antiviral infection research.

MerTK-IN-3 (compound 11) is an orally active, selective inhibitor of MerTK, exhibiting IC50 values of 21.5 nM for MerTK and 991.3 nM for Tyro3. It is applicable in colon cancer research.

<p>2,4-Xylidine hydrochloride is a bioactive chemical.</p>

KLHDC2ligand 1 is an E3 ligase ligand (E3 ligase Ligand) that can be utilized in the synthesis of PROTACBRD4 Degrader-31.

Timonacic, (S)- is a heterocyclic compound and the stereoisomer of Timonacic, suitable for biochemical experiments and drug synthesis research.

Decane, 1-fluoro- is a biochemical.

GT-02216 is capable of binding allosterically to GCase, thereby enhancing its function. In primary human fibroblasts, it increases GCase activity and decreases Tau accumulation in mutant GBA1 fibroblasts. Additionally, GT-02216 offers protection to hippocampal primary neurons exposed to Tau oligomer in a rat model.

m-Acetotoluide is a bioactive chemical.

CW8001 is a covalent Exportin-1 (XPO1) inhibitor with an EC50 value of 1 nM for inhibiting T cell activation. It prevents the nuclear localization of NFAT transcription factors, thereby suppressing the expression of inflammatory cytokines like IL-2. CW8001 shows potential for research in T cell-driven immune diseases such as graft-versus-host disease (GVHD).

m-Acetylphenyl acetate is a bioactive chemical.

Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.

(±)-Tuaimenal A ((+)-1) is a secondary metabolite and a derivative of Sesamol. It exhibits potent inhibitory activity against SARS-CoV-2 3CLpro, with an IC50 of 33.3 μM. (±)-Tuaimenal A is applicable in research related to SARS-CoV-2 infection.

GLP-1R agonist 33 (Compound 224) is a GLP-1 receptor agonist with potential applications in research related to diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).

Fexinidazole, an antiparasitic, targets T. cruzi, T. foetus, T. vaginalis, E. histolytica, T. brucei, L. donovani. Active forms: sulfoxide, sulfone.

Neritaloside is a natural product from Nerium oleander.

Henicosafluoro-10-iododecane is a biochemical.

Tubulin polymerization-IN-79 (Compound C20) acts as an inhibitor of microtubule polymerization. It exhibits significant antiproliferative activity against esophageal cancer cells, such as KYSE450 (IC50=0.36 μM) and EC-109 (IC50=0.63 μM). In esophageal cancer cells, Tubulin polymerization-IN-79 occupies the colchicine binding site, disrupting the microtubule network's integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP, and inducing G2/M phase arrest and apoptosis. This compound shows promise for esophageal cancer research.

Decane, 1,1'-thiobis- is a biochemical.

Y2641, a tetrahydro β-carboline derivative, is an orally active dual inhibitor of RANKL and TNF-α, with Kd values of 3.984 μM and 18.59 μM respectively. It suppresses RANKL-induced osteoclastogenesis and exhibits anti-inflammatory and cartilage-protective properties. Y2641 is applicable in osteoarthritis research.

SHOC2–RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor that targets the interaction between SHOC2 and RAS proteins. It exhibits an IC50 of 0.048 μM and a KD of 0.065 μM against NRASQ61R. This compound inhibits SMP phosphatase-complex activity, increasing CRAFS259 phosphorylation levels and thus blocking the MAPK signaling pathway (by reducing pMEK and pERK levels). It induces cell cycle arrest and apoptosis in tumor cells. SHOC2–RAS PPI-IN-1 is used in targeting studies for malignancies, such as NRASQ61R-mutant melanoma and colorectal cancer.