CymitQuimica ha oltre 25 partner, tra i quali spicca il fornitore TargetMol

GIP/GLP-1 dual receptor agonist-1 (Compound 4) (sodium) functions as a GIP/GLP-1 receptor agonist. This compound is applicable for research into metabolic disorders and liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).

Berobenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist.

Zovaglutide is a GLP-1 receptor agonist that is utilized in diabetes research.

L-Phenylalanyl-L-threonine is a dipeptide composed of phenylalanine and threonine, which can be utilized in the synthesis of the cyclic hexapeptide [Banyascyclamide A].

Acmopatide (Compound E-153) is a dual agonist of GIP and GLP-1 receptors and can be utilized in diabetes research.

JKC 302 is an ET-A receptor antagonist that partially inhibits the contraction of tracheal rings in asthmatic rats induced by ET-1.

P9R is an antiviral peptide with broad-spectrum activity against coronaviruses (SARS-CoV-2, MERS-CoV, and SARS-CoV), influenza A H1N1 virus (A(H1N1)pdm09), influenza A H7N9 virus (A(H7N9) virus), and rhinovirus. It binds directly to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from infection by influenza A H1N1 virus (A(H1N1)pdm09) without leading to resistant viruses. P9R is applicable in studying pH-dependent respiratory viruses.

Targeting thebacterialsliding clamp peptide 46 TFA is a short peptide that specifically targets the bacterial sliding clamp (SC) and inhibits SC-dependent DNA synthesis.

TE-8105 is a GLP-1 receptor agonist that demonstrates prolonged and enhanced efficacy in models of diabetes, obesity, and non-alcoholic steatohepatitis (NASH).

Canine KP-10 is a potent kisspeptin that induces a significant gonadotropin and estradiol response in female dogs during estrus.

Secretin, canine TFA, is an endocrine hormone that stimulates the secretion of pancreatic fluid rich in bicarbonate. Additionally, Secretin, canine TFA, can regulate the primary cell functions and paracellular permeability of gastric monolayer cells through an Src kinase-dependent pathway.

Zenagamtide is an agonist for both glucagon-like peptide-1 (GLP-1) and amylin receptors.

WT1 126-134 peptide is a WT1 polypeptide (Wilms' tumor 1 peptide) (RMFPNAPYL) that activates cytotoxic CD8 T cells to target and destroy WT1+ tumor cells. It can form stable complexes with either H-2Db (murine) or HLA-A0201 (human) molecules. The WT1 126-134 peptide/HLA-A0201 complex exhibits high affinity for humanized monoclonal antibodies (IgG1), with a dissociation constant (Kd) of 0.2 nM. This peptide can be utilized as a T cell vaccine or an antibody target.

G-Pen-GRGDSPCA TFA is an αvβ3 inhibitory RGD peptide. It inhibits neointimal hyperplasia and luminal narrowing following vascular injury and regulates the migration and proliferation of smooth muscle cells. This compound can be utilized in studies related to mechanisms of vascular injury repair.

L803 is a selective somatostatin receptor type 4 (SST4) agonist that can inhibit L-type calcium channel currents (ICa). It holds potential for research into degenerative diseases of retinal ganglion cells (RGC), such as glaucoma.

Pelteobagrin is a broad-spectrum antimicrobial peptide targeting Gram-positive bacteria, Gram-negative bacteria, and fungi (MIC=2-16 μg/mL). It exerts its bactericidal effects by non-competitively disrupting the integrity of cell walls and cytoplasmic membranes. Pelteobagrin holds promise for use in infectious disease research.

GEP44 is a peptide-biased triple agonist targeting the glucagon-like peptide-1 receptor (GLP-1R), neuropeptide Y1 receptor (Y1-R), and neuropeptide Y2 receptor (Y2-R). It induces GLP-1R-dependent insulin secretion in rat and human islets by offsetting the actions of Y1-R and GLP-1R agonism, controlled by Y1-R antagonists. Additionally, GEP44 enhances glucose uptake in muscle tissue through Y1-R mediation independent of insulin and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 is utilized in studies related to obesity and type 2 diabetes.

c(R3W4V) is an antimicrobial peptide with a stable transmembrane structure. It exhibits inhibitory concentrations (IC50) of 0.27 μM for E. coli, 0.46 μM for S. aureus, and 0.05 μM for B. subtilis.

NN1213 (Peptide 21) is a long-acting human amylin peptide analogue that functions as a selective amylin receptor agonist. It has an EC50 of 0.177 nM for hAMY3R and 0.262 nM for rAMY3R. In both rat and dog models, NN1213 significantly reduces appetite and is utilized in anti-obesity research.

C-telopeptide TFA is a cross-linked peptide of type I collagen, released during bone resorption, and is associated with bone mineral density (BMD).