CymitQuimica ha oltre 25 partner, tra i quali spicca il fornitore TargetMol

<p>DOSPA hydrochloride is a cationic lipid utilized in the formation of lipid nanoparticles.</p>

<p>Benzyl N1-[PEG1-NHS]-N6-(t-Boc)-L-lysinate is a versatile ADC linker composed of a terminal benzyl group, a PEG unit, an NHS ester, and L-lysine protected with a t-Boc group. It is frequently utilized in research and development for bioconjugation and chemical modification.</p>

<p>NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker that features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB component is suitable for attaching reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine is versatile for reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, or other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular cathepsins, allowing efficient payload delivery via an elimination mechanism through the PAB structure.</p>

<p>11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.</p>

<p>MC-Val-Ala-NHS ester is a cleavable ADC linker featuring maleimide and NHS ester groups. The Val-Ala linker is susceptible to cleavage by cathepsin B. The maleimide group can react with thiol groups, as can the MC component. The NHS ester reacts specifically and efficiently with amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or mildly alkaline conditions, forming covalent bonds. Reagent grade, intended for research use only.</p>

<p>(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.</p>

<p>3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.</p>

<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>

<p>BrAc-Val-Ala is an ADC linker, utilized for synthesizing antibody-drug conjugates (ADC) such as ABBV-969.</p>

<p>5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine.</p>

<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>

<p>Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB is an ADC linker characterized by its reactivity with interchain cysteine through maleimide and cleavability by β-glucuronidase. It is utilized in the synthesis of antibody-drug conjugates (ADCs), such as AZD0516.</p>

<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>

<p>(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.</p>

<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>

<p>N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine serves as a PEGn linker for antibody-drug conjugates (ADC).</p>

<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>

<p>MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate that forms part of the antibody-antibiotic conjugate (AAC) molecule. It is synthesized by conjugating the linker with the antibiotic Gemcitabine. This compound is useful in studying the immunotherapy of bacterial infections and developing novel antibacterial drugs.</p>

<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>