CymitQuimica ha oltre 25 partner, tra i quali spicca il fornitore TargetMol

ZnPc-O3-JQ1 is a light-activated BRD4 degrader. Under light exposure, ZnPc-O3-JQ1 generates reactive oxygen species (ROS), leading to the degradation of BRD4. This degradation results in the downregulation of HIF-1α, effectively countering the tumor hypoxia-induced resistance to photodynamic therapy (PDT). ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 includes three components: a BRD4 ligand, a linker, and a photosensitizer.

3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid is a reactive oxygen species (ROS) sensitive degradable linker utilized in the synthesis of antibody-drug conjugates (ADC). This compound shows potential for application in the research of tumor drug delivery systems.

Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.

Lansoprazole sulfide (AG-177) is an active metabolite of Lansoprazole .Lansoprazole is a proton pump inhibitor and antitubercular agents M.TB.

STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.

Hydrotecan is an auristatin derivative utilized as an ADC cytotoxin, and it serves as a component in the synthesis of ADC molecules.

Axitinib sulfoxide is a major metabolite of Axitinib, which is a VEGFR tyrosine kinase inhibitor and may be useful in cancer therapy.

HDAC6degrader-6 (compound 10c) is a ByeTAC degrader specifically targeting HDAC6 and exhibits inhibitory effects on HDAC6, HDAC1, HDAC2, and HDAC3, with IC50 values noted. HDAC6degrader-6 induces apoptosis and is applicable for research in multiple myeloma.

<p>PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.</p>

Precocene II (Ageratochromene) blocks juvenile hormone, has insecticidal, antifungal, antibacterial, and antioxidant properties.

HDAC6ligand-Linker Conjugate 1 is a conjugate of the ligand and linker for HDAC6 (Target Protein Ligand-Linker Conjugate) and can be utilized in the synthesis of PROTACs such as PROTACHDAC6 degrader5.

Neomycin C hexaacetate is a tetracyclic antibacterial agent and the primary active isomer in the neomycin complex. Neomycin, an aminoglycoside containing 2-DOS, is composed of Neomycin A, Neomycin B, and Neomycin C.

PROTACSARS-CoV-2 Degrader-1 (Compound LLP019) is a PROTAC degrader that targets the main protease (MPro) of SARS-CoV-2 with a DC50 value of 4.7 μM. It facilitates the ubiquitination and proteasomal degradation of MPro, thereby hindering the replication of SARS-CoV-2. This compound holds potential for research into COVID-19 and related coronavirus infections.

<p>NASTRp inhibits CREB-CBP, has anti-cancer properties, regulates cell cycle, suppresses autophagy, and induces ER stress.</p>

MCC-AAQ-Exa is a drug-linker conjugate, formed by the condensation of a linker with Exatecan, suitable for the preparation of antibody-drug conjugates (ADC). The MCC component contains a maleimide moiety within the ADC linker.

Nek2/Hec1-IN-3 (Compound 11-28) is an inhibitor of the Hec1/Nek2 interaction. It disrupts the binding between Nek2 and Hec1 and is applicable for research in tumor diseases.

CH091138 is a potent and selective KRASG12D PROTAC degrader, exhibiting a DC50 value of 148.3 nM in HeLa cells and 469.8 nM in AsPC-1 cells. It selectively targets both exogenous and endogenous KRASG12D through the VHL-mediated ubiquitin-proteasome system, without affecting KRASWT or other KRAS mutants (G12C/G12S/G12V). CH091138 demonstrates significant antitumor activity by inducing apoptosis (apoptosis) in tumor cells and is applicable for research in pancreatic and colon cancers.

<p>Aglepristone: synthetic steroid, antiprogestogen, some antiglucocorticoid effect, used as abortifacient in animals.</p>

<p>Decane, 1,10-dibromo- is used as synthetic organic intermediate and as an alkylating agent.</p>

1,10-Diiododecane: Crosslinks polygalacturonic acid, alkylates bis-cryptophanes, produces decane at 20°C.