Do you know TargetMol inhibitors?
Today we want to talk about inhibitors. Inhibitors are small molecules that can bind to proteins and reduce their activity. They can be applied to many different cells, have good permeability across the membrane and are stable.
Inhibitors are used in many fields of research, for studies on signaling, cell cycle, metabolism and even stem cells. In CymitQuimica you can find different inhibitors that intervene in signaling processes such as angiogenesis, apoptosis, MAPK, NF-KB, proteases, etc. Inhibiting these pathways allows us to instigate where and how the different processes occur.
A variety of Targetmol inhibitors have been used in research. Here are some examples of important studies where they appear:
- Chenodeoxycholic acid : Sun, L., Xie, C., Wang, G. et al. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nat Med 24, 1919-1929 (2018). https://doi.org/10.1038/s41591-018-0222-4
- AZD-7762: Mooser, C., Symeonidou, IE., Leimbacher, PA. et al. Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation. Nat Commun 11, 123 (2020). https://doi.org/10.1038/s41467-019-13981-x
- Docetaxel : Li, Q., Qin, T., Bi, Z. et al. Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer. Nat Commun 11, 1456 (2020). https://doi.org/10.1038/s41467-020-15308-7
At CymitQuimica we have a wide range of inhibitors available. Find the inhibitor you need here.