The tetrapeptide DAHK corresponding to the N-terminal sequence of human serum albumin forms a tight binding site for Cu(II) ions. DAHK inhibits Cu(II)-induced oxidative DNA double strand breaks. The tetrapeptide is as effective as HSA in preventing neuronal death induced by CuCl2/ascorbic acid. DAHK may be an effective, small-molecular-weight alternative to HSA as a therapeutic agent for stroke.
Technical inquiry about: 01-4009490 H-Asp-Ala-His-Lys-OH
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