SASRIN™ resin (200-400 mesh, 0.80-1.20 mmol/g)
- 2-Methoxy-4-alkoxybenzyl alcohol resin (200-400 mesh)
SASRINTM (=Super Acid Sensitive ResIN) was developed in our own laboratories especially for Fmoc solid phase synthesis (EP 0 292 729, US 4,831,084 and US 4,914,151). Its high acid lability enables the cleavage and isolation of the protected peptide fragment. Beside SPPS SASRINTM has been used in several organic reactions like the synthesis of 4-aryl substituted b-lactams employing Suzuki and Heck couplings, the synthesis of b-sultams, quinazoline-2,4-diones, pyridines and pyrido[2,3-d]pyrimidines and the generation of secondary alkylamines by borane reduction. S.S.Rahman et al. reported on the FT-IR and Raman spectroscopic monitoring of reactions on a single SASRINTM bead and C.L.Brummel et al. on the evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. For a review on the manifold applications of our SASRINTM resin, including many useful procedures, please ask for our SASRINTM brochure.
Technical inquiry about: 01-4012712 SASRIN™ resin (200-400 mesh, 0.80-1.20 mmol/g)
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