Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone

CAS: 118253-05-7

Ref. 01-4025803

Product Information

• Name: Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone
• Synonyms: Z-FK-ck
• Brand: Bachem
• Description: Z-FK-ck is a very effective in vivo cathepsin B inhibitor in rats. It inhibited rat liver cathepsin B activity ex vivo with ED₅₀ = 5 mg/kg intraperitoneally and 18 mg/kg orally at 4-5 h postdose, and 2.4 mg/kg subcutaneously at 24 h postdose. It also inhibited rat cathepsin B activity in heart and skeletal muscle with ED₅₀ = 0.1 and 1.0 mg/kg subcutaneously at 20 h postdose. Z-FK-ck is an inhibitor of gingipain K.

Chemical properties

• Molecular weight: 587.72
• Formula: C₃₄H₄₁N₃O₆
• Purity: 92.4%
• Color/Form: White