- (D-Phe¹²,Nle²¹·³⁸,cyclo(Glu³⁰-Lys³³))-CRF (12-41) (human, rat)
The Glu30 to Lys33 lactam bridge constrains astressin in an a-helical conformation which seems to be responsible for its especially high CRF antagonist activity. Astressin is 100 times more potent than a-helical CRF (9-41) at inhibiting ACTH secretion in vitro, and more than 10 times more potent in vivo than any other CRF antagonist reported to date.
Technical inquiry about: 01-4026664 Astressin
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