L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

CAS: 88321-09-9

Ref. 01-4027911

Product Information

• Name: L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester
• Synonyms: L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-, Aloxistatin, E 64c ethyl ester, E-64d, E64d, E64d/pepstatin, EST, EST (pharmaceutical), Ep 453, Loxistatin, NSC 694281, Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-, Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-, Pepstatin E64d, ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate, ethyl (2S,3S)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate

Description

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer’s disease animal models.

• Brand: Bachem

Chemical properties

• Molecular weight: 342.44
• Formula: C₁₇H₃₀N₂O₅
• Purity: > 99%
• Color/Form: White