Product Information
- GHRP amide
The central E region of fibrin contains two sets of polymerization knobs, A and B, that are cryptic in fibrinogen but become exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aa- and Bb-chains, respectively. The location of the binding holes and possible models for knob-hole interactions are known from X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and double-D are crystallized in the presence of both peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH2 (GPRP-amide) forms H-bond interactions with residues g364Asp, g330Asp, g329Gln, and g340His found in hole a. In the same manner, the knob B peptide mimic H-Gly-His-Arg-Pro-NH2 (GHRP-amide) interacts with residues Bb397Glu, Bb398Asp, and Bb432Asp in hole b.
Chemical properties
Technical inquiry about: 01-4075030 H-Gly-His-Arg-Pro-NH₂
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.
