Product Information
- L-Lysine, L-lysyl-L-α-glutamylglycyl-L-valyl-L-leucyl-L-tyrosyl-L-valylglycyl-L-seryl-L-lysyl-L-threonyl-
- α-Synuclein (34-45) (human) trifluoroacetate salt
The Parkinson’s disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
Chemical properties
Technical inquiry about: 01-4107367 α-Synuclein (34-45) (human)
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.
