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(Des-Glu22)-Amyloid b-Protein (1-40)
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(Des-Glu22)-Amyloid b-Protein (1-40)

CAS: 1678416-36-8

Ref. 01-H-7474

1mg
319.00 €Add to cart
0.5mg
190.00 €Add to cart
Estimated delivery in United States, on Wednesday 15 Dec 2021

Product Information

Name:
(Des-Glu22)-Amyloid b-Protein (1-40)
Synonyms:
  • Amyloid b-Protein (1-40) Osaka or Japanese Mutation, Amyloid b-Protein (1-40) E22D
Description:
The Osaka mutation was the first deletion-type mutation to be identified in APP and Ab. The Ab E22delta mutant is more resistant to degradation by two major Ab-degrading enzymes, neprilysin and insulin-degrading enzyme. Synthetic mutant Ab showed unusual aggregation properties with enhanced oligomerization but no fibrillization. It also inhibited hippocampal long-term potentiation more efficiently than wild-type Ab. A transgenic mouse model containing APP with the E693delta mutation has been developed. APP(OSK)-Tg mice exhibit intraneuronal Ab E22delta oligomers and memory impairment as early as eight months of age.
Long term storage:
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Chemical properties

Molecular weight:
4198.10583
Formula:
C189H288N52O55S
Purity:
>91%
Color/Form:
White Powder
MDL:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Technical inquiry about: 01-H-7474 (Des-Glu22)-Amyloid b-Protein (1-40)

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