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Mca-(Ala7,Lys(Dnp)9)-Bradykinin
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Mca-(Ala7,Lys(Dnp)9)-Bradykinin

CAS: 323577-36-2

Ref. 01-M-2405

1mg
512.00 €Add to cart
5mg
1,867.00 €Add to cart
Estimated delivery in United States, on Monday 13 Dec 2021

Product Information

Name:
Mca-(Ala7,Lys(Dnp)9)-Bradykinin
Synonyms:
  • L-Lysine,N2-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-(9CI)
  • 61: PN: WO03065997 SEQID: 91 unclaimed protein
  • Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-Oh
Description:
Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 107 M-1s-1 and 1.7 x 106 M-1s-1 for the hydrolysis by neprilysin. This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M-1s-1 and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M-1s-1). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.
Long term storage:
Notes:

Chemical properties

Molecular weight:
1387.58332
Formula:
C66H81N15O19
Purity:
> 95%
Color/Form:
Yellow Lyophilisate
MDL:
Melting point:
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EINECS:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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