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L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, E-64d, EP453, Aloxistatin, Loxistatin
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L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, E-64d, EP453, Aloxistatin, Loxistatin

CAS: 88321-09-9

Ref. 01-N-1650

1mg
127.00 €Add to cart
5mg
476.00 €Add to cart
Estimated delivery in United States, on Tuesday 7 Dec 2021

Product Information

Name:
L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, E-64d, EP453, Aloxistatin, Loxistatin
Synonyms:
  • L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, E-64d, Loxistatin, EP453, Aloxistatin
  • 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
  • Aloxistatin
  • E 64c ethyl ester
  • E-64d
  • E64d
  • E64d/pepstatin
  • EST
  • EST (pharmaceutical)
  • Ep 453
  • See more synonyms
  • Loxistatin
  • NSC 694281
  • Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
  • Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-
  • Pepstatin E64d
  • ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate
  • ethyl (2S,3S)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate
Description:
E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing b-secretase activity, E64d could reduce brain Ab and improve memory deficits in Alzheimer's disease animal models.
Long term storage:
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Chemical properties

Molecular weight:
342.21547
Formula:
C17H30N2O5
Color/Form:
White
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Hazard Info

UN Number:
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Forbidden to fly:
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Technical inquiry about: 01-N-1650 L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide, E-64d, EP453, Aloxistatin, Loxistatin

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