07-A5156 - actinomycin-d-mannitol-lyophilized-powder

<p>Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. </p>

<p>Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm?s tumor and the sarcomas. This Thermo </p>

<p>Actinomycin D</p>

<p>M01247 - Actinomycin D</p>

<p>Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),<br></p>

<p>An analogue of Actinomycin D and an antitumor agent. Due to lower hepatotoxicity, Actinomycin V is more often used than Actynomycin D in chemotherapy and shows great efficiency against human breast cancer cells.</p>

<p>Actinomycin D1 is a DNA inhibitor.</p>

<p>Actinomycin D2 is a DNA inhibitor.</p>

Antibiotics nesoi

<p>Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator , inhibits transcription DNA, serving as a chemotherapy drug for cancer treatment.</p>

<p>Actinomycin D is an antibiotic commonly used in chemotherapy for cancer treatment, such as sarcomas, and pediatric solid tumors, Wilm’s tumor, testicular cancer, and choriocarcinoma; it is generally not very useful in antibiotic therapy. It acts as a transcription inhibitor, binding to DNA duplexes at the transcription initiation complex and preventing RNA polymerase elongation.</p>

<p>Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins.</p>