Vandetanib - Bio-X ™

CAS: 443913-73-3

Ref. 3D-BV164508

Product Information

• Name: Vandetanib - Bio-X ™
• Synonyms: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[ (1-methylpiperidin-4-yl)methoxy]quinazolineZD 6474, 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline, 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-, Azd-6474, Azd6474, Caprelsa, Ch 331, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazolin-4-amine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine, N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-[(1-methyl-4-piperidyl)methoxy]quinazolin-4-amine, Vandetanib, Zactima, ZD6474, Zactima, Zd-6474
• CAS: 443913-73-3

Description

Vandetanib is antineoplastic kinase inhibitor that binds to the ATP-binding site of the enzyme squamous cell carcinoma kinase (SQSTM1). This binding inhibits the phosphorylation of the Bcl-2 protein and causes apoptosis. Vandetanib has been shown to have an effect on polymerase chain reaction amplification, terminal erythrocyte differentiation, and on gene expression in human tissue.

Vandetanib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

• Brand: Biosynth

Chemical properties

• Molecular weight: 475.35 g/mol
• Formula: C₂₂H₂₄BrFN₄O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
• InChI key: InChIKey=UHTHHESEBZOYNR-UHFFFAOYSA-N
• SMILES: COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1