Dengue Virus NS1 Antigen Mouse Monoclonal Antibody

Ref. 3D-CM1191

Product Information

• Name: Dengue Virus NS1 Antigen Mouse Monoclonal Antibody
• Brand: Biosynth
• Description: With specificity to all four serotypes (DEN-1, DEN-2, DEN-3 and DEN-4) of the Dengue virus NS1 protein, this mouse monoclonal antibody is protein A purified from ascites fluids and presented as a liquid in 0.01M PBS, pH 7.2. IgG1 immunoglobulin subclass clones are available and can be used in ELISA or later flow assays. Specifically Clone 0801036 can be used as a capture antibody with either clone 0801046 or 0801056 as the detection antibodies in ELISA. In lateral flow assays clone 1509107 can be used as the capture antibody along with clone 1609117 as the detection antibody. Therefore monoclonal antoibodies such as this product can be used in the detection and diagnosis of Dengue virus in human patients.Classified as a Flavivirus and a member of the Flaviviridae family, the Dengue virus, through mosquito transition causes dengue fever in humans. Although this virus can inflict asymptomatic or mild symptoms in patients it can lead to severe infections such as dengue hemorrhagic fever, also known as dengue shock syndrome. The Dengue Virus non-structural protein 1 (NS1) to which this mouse monoclonal antibody is complementary, is an important glycoprotein antigen in Dengue viral replication and is secreted from infected host cells as a hexamer. As a secreted hexamer the NS1 protein contains a detergent-sensitive central cavity, hosting around 70 lipid molecules which may allow the NS1 through glycosaminoglycan interactions, to attach to the cell membranes of the host cells. Once the NS1 is anchored into the surface membrane of infected host cells it appears as a membrane associated homodimer. It is believed that NS1 may interact with complement proteins leading to protection of the Dengue virus from complement-dependent lysis and furthermore may be involved in systemic immunity and contribute to vascular leakage, coagulopathy and thromobocytopenia.

Chemical properties

• Purity: >90% By Immunoelectrophoresis Using Agarose.