NEFL (38-54) Light

Ref. 3D-CRB1001258

Product Information

• Name: NEFL (38-54) Light
• Synonyms: H-SAYSSYSAPVSSSLSVR-OHNeurofilament light polypeptideNeurofilament triplet L proteinNF-LSAYSSYSAPVSSSLSVR-acidH-Ser-Ala-Tyr-Se r-Ser-Tyr-Ser-Ala-Pro-Val-Ser-Ser-Ser-Leu-Ser-Val-Arg-OHLR12
• Brand: Biosynth
• Description: Residues 38-54 of neurofilament light polypeptide (NEFL), a neuronal intermediate filament (IF) which forms the major cytoskeletal structure of the axon. Neurofilaments help maintain the morphology of neurons, regenerate myelinated axons, and help transport neurotransmitters to axons and dendrites.The NEFL gene is located in the chromosomal region 8p21, which is a genetic locus frequently found to have deletions in a variety of common human cancers. Perturbations in NEFL have been linked to a number of cancers including breast cancer and head and neck cancer and NEFL-has been shown to act as a tumour suppressor. In addition to its role in cancers, mutations in NEFL have also been linked to motor neuron diseases, such as Charcot-Marie-Tooth disease (CMT).

Chemical properties

• Molecular weight: 1,746.8 g/mol
• Purity: Min. 95%