Product Information
- 1,3-Benzoxazole-2-carboxamide
- 2-Benzoxazolecarboxamide(7CI,8CI,9CI)
Benzooxazole-2-carboxylic acid amide is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with IC50 values in the low nanomolar range. It also inhibits the activation of EGFR by other growth factors, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGFα). Benzooxazole-2-carboxylic acid amide has been shown to inhibit tumor cell proliferation in vitro and in vivo. The mechanism of action is not fully understood but may involve interference with repair mechanisms that are activated by DNA damage. The drug binds to the EGFR receptor and prevents its phosphorylation by other molecules, which would otherwise activate it.
Chemical properties
Technical inquiry about: 3D-DAA31338 Benzooxazole-2-carboxylic acid amide
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