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Aprocitentan
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Aprocitentan

CAS: 1103522-45-7

Ref. 3D-DUB52245

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Estimated delivery in United States, on Thursday 23 May 2024

Product Information

Name:
Aprocitentan
Synonyms:
  • Act-132577
Description:

Apcitentan is a vasoactive drug that belongs to the group of endothelin receptor antagonists. It is used in the treatment of erectile dysfunction and pulmonary hypertension. Apcitentan inhibits the angiotensin system, which includes angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R). This inhibition increases the levels of endothelin and dopamine β-hydroxylase, thereby decreasing blood pressure. Apcitentan has been shown to increase glomerular filtration rate and reduce proteinuria in patients with chronic kidney disease. In vivo studies have shown that apcitentan is rapidly absorbed from the gastrointestinal tract, reaching peak concentrations within one hour. The pharmacodynamics of apcitentan are characterized by an inhibitory effect on pde5. Pharmacokinetic studies have found that apcitentan is metabolized by CYP

Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
546.19 g/mol
Formula:
C16H14Br2N6O4S
Purity:
Min. 95%
MDL:
Melting point:
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Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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