Amyloid β-Protein (16-20) trifluoroacetate salt

CAS: 153247-40-6

Ref. 3D-FA109060

Product Information

• Name: Amyloid β-Protein (16-20) trifluoroacetate salt
• Synonyms: H-Lys-Leu-Val-Phe-Phe-OH trifluoroacetate salt
• Brand: Biosynth
• Description: Amyloid beta-protein (Aβ) is a peptide that is associated with the development of Alzheimer's disease. The Aβ(16-20) trifluoroacetate salt (ATF) has been used in the diagnosis of Alzheimer's disease by fluorescence microscopy. This compound binds to hyaluronic acid and has been used as a coating for optical fibers and other materials, such as coatings for mitochondria for use in live cell imaging. The ATF also interacts with mitochondria and alters mitochondrial membrane potential, which may be due to its ability to displace cardiolipin from the inner mitochondrial membrane. ATF binds to unsymmetrical dimethylarginine (DMA), an endogenous nitric oxide synthase inhibitor, and selectively inhibits only cancer cells that have elevated levels of DMA. ATFP also induces spontaneous apoptosis in human carcinoma cells when bound to these cells via a photoconjugation reaction with bioconjugate chemistry.

Chemical properties

• Molecular weight: 652.82 g/mol
• Formula: C₃₅H₅₂N₆O₆
• Purity: Min. 95%