(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P
CAS: 96736-12-8
Ref. 3D-FA109992
| 1mg | 223.00 € | ||
| 2mg | 364.00 € | ||
| 5mg | 646.00 € | ||
| 10mg | 1,047.00 € | ||
| 25mg | 2,142.00 € |
Product Information
- H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 H-(dR)PKP(dF)Q(dW)F(dW)LL-NH2
- SubstanceP,1-D-arginine-5-D-phenylalanine-7-D-tryptophan-9-D-tryptophan-11-L-leucinamide-
- L 756867
- [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P
- D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2
Substance P is a neuropeptide that binds to the tachykinin receptor NK1. It has potent anti-inflammatory and mitogenic activities, which are mediated through its binding to the NK1 receptor. Substance P can stimulate lung cancer cells to proliferate and inhibit their apoptosis, which may be due to an autocrine mechanism. In addition, it has been shown that substance P can potentiate the growth of some cancers such as colon cancer in vitro and in vivo by increasing DNA synthesis and cell proliferation. This peptide also has a dose-dependent effect on cell growth, with high doses inhibiting cell proliferation at higher levels than low doses.
Chemical properties
Technical inquiry about: 3D-FA109992 (D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P
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