H-Asn-Glu-Ala-Tyr-Val-His-Asp-Ala-Pro-Val-Arg-Ser-Leu-Asn-OH

CAS: 143305-11-7

Ref. 3D-FA110895

Product Information

• Name: H-Asn-Glu-Ala-Tyr-Val-His-Asp-Ala-Pro-Val-Arg-Ser-Leu-Asn-OH
• Synonyms: H-NEAYVHDAPVRSLN-OH, N-E-A-Y-V-H-D-A-P-V-R-S-L-N
• Brand: Biosynth
• Description: H-Asn-Glu-Ala-Tyr-Val-His-Asp-Ala-Pro-Val-Arg-Ser-Leu-Asn is a cytosolic protein that is an inhibitor of protein synthesis. It has been shown to inhibit the activity of proteases, such as caspase 1, and to activate caspase 1. This inhibition is consequent to the inhibition of polypeptide chain elongation and may be due to the ability of HAAHTVHAAPVVAALAHPVKVALARGSRLEUANNSOH to bind to peptidyl transferase or other proteins involved in protein synthesis. HAAHTVHAAPVVAALAHPVKVALARGSRLEUANNSOH binds to primary keratinocytes and k562 cells more efficiently than it does to thp1 cells, suggesting that it may have a role in skin cancer.

Chemical properties

• Molecular weight: 1,584.69 g/mol
• Formula: C₆₈H₁₀₅N₂₁O₂₃
• Purity: Min. 95%