2-(1,1'-Biphenyl-4-yl)acetohydrazide
CAS: 139277-58-0
Ref. 3D-FB114282
| 1g | Discontinued | ||
| 2g | Discontinued | ||
| 5g | Discontinued | ||
| 10g | Discontinued | ||
| 500mg | Discontinued |
Product Information
Name:
2-(1,1'-Biphenyl-4-yl)acetohydrazide
Synonyms:
- 4-Biphenylacetic Hydrazide
- Akos B015277
- Art-Chem-Bb B015277
- Chembrdg-Bb 3015277
- 2-Biphenyl-4-Ylacetohydrazide
Description:
2-(1,1'-Biphenyl-4-yl)acetohydrazide is a covalent inhibitor of monoamine oxidases A and B. It has been shown to be an effective inhibitor of the enzymes with a Ki value of 0.2 µM for MAO-A and 1.5 µM for MAO-B. 2-(1,1'-Biphenyl-4-yl)acetohydrazide is structurally related to selegiline and benzylamine, which are also inhibitors of these enzymes. The inhibition mechanism is thought to be competitive inhibition by the molecule binding to the active site on the enzyme's surface. Inhibition of monoamine oxidase leads to increased levels of monoamines in the brain that have been implicated in cognitive disorders such as Alzheimer's disease and Parkinson's disease.
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
226.27 g/mol
Formula:
C14H14N2O
Purity:
Min. 95%
InChI:
InChI=1S/C14H14N2O/c15-16-14(17)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10,15H2,(H,16,17)
InChI key:
InChIKey=MLSJQOUEHHYKAD-UHFFFAOYSA-N
SMILES:
NNC(=O)Cc1ccc(-c2ccccc2)cc1
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