Z-gly-Pro-OH

CAS: 1160-54-9

Ref. 3D-FG40278

Product Information

• Name: Z-gly-Pro-OH
• Synonyms: (Benzyloxycarbonyl)glycyl-<span class="text-smallcaps">L</span>-proline, <span class="text-smallcaps">L</span>-Proline, 1-[N-[(phenylmethoxy)carbonyl]glycyl]-, <span class="text-smallcaps">L</span>-Proline, N-[(phenylmethoxy)carbonyl]glycyl-, Carbobenzoxyglycyl-<span class="text-smallcaps">L</span>-proline, Cbz-gly-pro-oh, N-Carbobenzoxyglycyl-L-proline, N-[(Phenylmethoxy)carbonyl]glycyl-<span class="text-smallcaps">L</span>-proline, NSC 89634, Proline, 1-(N-carboxyglycyl)-, N-benzyl ester, <span class="text-smallcaps">L</span>-, Z-Gly-Pro-Oh
• CAS: 1160-54-9

Description

Z-gly-Pro-OH is a synthetic peptide substrate that has been used to study the activity of serine proteases, specifically histidine-specific proteases. It has been shown to be hydrolyzed by human liver and intestinal enzymes, including serine proteases, in vitro. This peptide also reacts with epirubicin, a drug that is used in chemotherapy for treating cancer. The reaction between the two compounds results in an increased potency of epirubicin and a decreased potency of z-gly-pro-OH. Z-gly-Pro-OH can be synthesized from L-histidine and glycylproline using the method of intramolecular hydrogenation to form an amide bond between the amino acid and the proline residue. The synthesis can be completed using a chromatographic method or titration method. This synthetic peptide is also used as a substrate for studying histidine specific peptidases, which are responsible for cle

• Brand: Biosynth

Chemical properties

• Molecular weight: 306.31 g/mol
• Formula: C₁₅H₁₈N₂O₅
• Purity: Min. 95%